SR9011 Description:

1. SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.

2. Recommended for use in peroxide cured coatings, sealants, and PCV-based plastisols. Performance properties include: good adhesion, good chemical resistance, good hardness, good heat resistance and high abrasion resistance.

SR9011 Biological Activity:

1. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure.

2. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

3. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver,

4. skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia.

5. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic 

Company description:
Wuhan Godbullraw Chemical Co.,ltd, founded in 2011, is a modern advanced enterprise specializing in custom synthesis and R&D and exportation of APIs, peptides, 
Sarms, Local anesthetics, plant extract etc, we build coopration with labs and factory qualitied with GMP, DMF, FDA in china and worldwild. 
We take advantage on integrating factory resources and lab customized projects.for customer demand, we continue to expand the industry chain in familiar areas, 
and at the same time we also keep develop new product supply chain.

We have 7 synthesis labs and 3 scale-up  labs and 3 analysis lab toatly spaced with 13500 square meters, basement of these experienced chemist with high educated, 
we have strong supply system and purity raw. As the shipping , we cooperate with 10 experienced shipping companies to make sure ETA by a safe delivery to worldwild

Our service: 
Quality:  Our products match CP and USP standard before comes out from factory and rechecked by third institution like Jonashik and scores well always, 
we supply test report credit 30$ for next order

Shipping: available to worldwide, ETA 12 days around,customer just only need to supply us ship info and then wait the order delivery after payment, 
we will supply tracking number immediately when pack sent out
we experienced on shipping, we can promise free reshipping if seized by custom unfortunately

Payment: T/T,,Bitcoin