1. GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.

2. A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit
 

3. the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator.

4. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM.

5. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.

6. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

7. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742.

8. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.
 

Our service: 
Quality:  Our products match CP and USP standard before comes out from factory and rechecked by third institution like Jonashik and scores well always, we supply test report credit 30$ for next order

Shipping: available to worldwide, ETA 12 days around,customer just only need to supply us ship info and then wait the order delivery after payment, we will supply track number immediately when pack sent out
we experienced on shipping, we can promise free reshipping if seized by custom unfortunately

Payment: T/T,,Bitcoin
................................................................................
how to order
email or message us that includes your order like formate below:
product A   100g
product B   10vials

delivery country: 

our sales will quote a total cost includeds shipping fees and each item fees in 12 hours regularly. our service will satisfy your purchase and supply professional guide
 

Our advantage:

Rich experience.

We have specialized in this field for 7 years. Our steroids and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries. And we have got very good feedback from our customers, and established long friendly relations of cooperation.

High quality products with the best price

1.All powders are factory directly supplying and have much in stock.

2.Before each powder send out, it all will be tested again by our technician, if the quality good, then it can be sent out to customers.

Professtional packing and fast delivery

1.Professtional team for packing, different country and quantity order have different packing way, sure package the products the best to your order.

2.We have mass stock, so that we can guarantee all the package can be sent out as soon as possible after you pay and should arrive your hands 3-7 days safely by DHL,TNT,FEDEX,HKEMS,UPS,etc.

Best pre-sell and after-sell service.

1.Once the package send out, tracking number and packing picture should email you later

2.For raw powder buyer, we also can help you cook steroid powder into injection and supply you all the things to make ready use injection, such as 10ml vials,0.22um-0.45um whatman filter,crimper machine and filter pump.

How to order

1. Let me know the products with quantity you are interesting and your requirement, you will get the best offer.

2. After we confirm all the details about the order, Products will send out within 24 hours after we received your payment(MoneyGram,，T/T  and Bitcoin are accepted).

3. Tracking No. will send to you within 2-3days.Usually after 7-15days you will received your package.

4. We will take care of your order till parcel to your door, and expecting for your further feedback, 24 hours on line for after-sale service.