1. Product Name:GDF-8   
 

2. Chemical Name:Growth Differentiation Factor 8
 

3. Other Names: Myostatin
 

4. MF:C221H366N72O67S
 

5. Appearance:White Lyophilized Powder
 

6. Purity: >98%

7.package: 1mg/vial, 10vials/box

 

GDF-8 description :

1. Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis:

muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

 

2. Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in

both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy

 

 

GDF-8 Discovery and sequencing:

1. The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene.

These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

 

2. Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass.

A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

 

Structure and mechanism of action:

1. Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long)

amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.

 

2. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle,

which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation.

When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

 

3. Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis.

However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

Clinical significance:

1. A technique for detecting mutations in myostatin variants has been developed. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue.

Myostatin-related muscle hypertrophy has an incomplete autosomal dominance pattern of inheritance.

 

2. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes)

have increased muscle bulk, but to a lesser degree.

 

3. In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene.

 

4. An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause: his body produces a normal level of functional myostatin; but,

because he is stronger and more muscular than most others his age, it is believed that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. He appeared on the television show, World's Strongest Toddler.

 

Therapeutic potential:
 

1. Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin.

A monoclonal antibody specific to myostatin increases muscle mass in mice and monkeys.

 

2. A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%).

It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.

 

3. It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012,

no myostatin-inhibiting drugs for humans are on the market.

 

4. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth., is no longer under development. Some athletes,

eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.Myostatin levels are effectively decreased by creatine supplementation.
 

Company description:

Wuhan Godbullraw Chemical Co.,ltd, founded in 2011, is a modern advanced enterprise specializing in custom synthesis and R&D and exportation of APIs, peptides, 
Sarms, Local anesthetics, plant extract etc, we build coopration with labs and factory qualitied with GMP, DMF, FDA in china and worldwild. 
We take advantage on integrating factory resources and lab customized projects.for customer demand, we continue to expand the industry chain in familiar areas, 
and at the same time we also keep develop new product supply chain.

You can contact me at any time if you need it.Our products are of high quality and competitive prices.

We have 7 synthesis labs and 3 scale-up  labs and 3 analysis lab toatly spaced with 13500 square meters, basement of these experienced chemist with high educated, 
we have strong supply system and purity raw. As the shipping , we cooperate with 10 experienced shipping companies to make sure ETA by a safe delivery to worldwild

Our service: 
Quality:  Our products match CP and USP standard before comes out from factory and rechecked by third institution like Jonashik and scores well always, 
we supply test report credit 30$ for next order

Shipping: available to worldwide, ETA 12 days around,customer just only need to supply us ship info and then wait the order delivery after payment, 
we will supply tracking number immediately when pack sent out
we experienced on shipping, we can promise free reshipping if seized by custom unfortunately

Payment: T/T,,Bitcoin

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how to order
email or message us that includes your order like format below:
product A   100g
product B   10vials

delivery country: 

our sales will quote a total cost includeds shipping fees and each item fees in 12 hours regularly. 
our service will satisfy your purchase and supply professional guide

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Our advantage:

Rich experience.

We have specialized in this field for 11 years. Our steroids and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries.
 And we have got very good feedback from our customers, and established long friendly relations of cooperation.

High quality products with the best price

1.All powders are factory directly supplying and have much in stock.

2.Before each powder send out, it all will be tested again by our technician, if the quality good, then it can be sent out to customers.

Professtional packing and fast delivery

1.Professtional team for packing, different country and quantity order have different packing way, sure package the products the best to your order.

2.We have mass stock, so that we can guarantee all the package can be sent out as soon as possible after you pay and should arrive your hands 3-7 days safely 
by DHL,TNT,FEDEX,HKEMS,UPS,etc.

Best pre-sell and after-sell service.

1.Once the package send out, tracking number and packing picture should email you later

2.For raw powder buyer, we also can help you cook steroid powder into injection and supply you all the things to make ready use injection, such as 10ml vials,
0.22um-0.45um whatman filter,crimper machine and filter pump